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Early cancer detection using the fluorescent Ashwagandha chitosan nanoparticles combined with near-infrared light diffusion characterization: in vitro study by Hala S. Abuelmakarem; Omnia Hamdy; Mahmoud A. Sliem; Jala El-Azab; Wafaa A. Ahmed is a Medicine article available to read on EtoBox.
What is Early cancer detection using the fluorescent Ashwagandha chitosan nanoparticles combined with near-infrared light diffusion characterization: in vitro study about?
## Abstract Early cancer diagnosis through characterizing light propagation and nanotechnology increases the survival rate. The present research is aimed at evaluating the consequence of using natural nanoparticles in cancer therapy and diagnosis. Colon cancer cells were differentiated from the normal cells via investigating light diffusion combined with the fluorescence effect of the Ashwagandha chitosan nanoparticles (__Ash C NPs__). Ionic gelation technique synthesized the __Ash C NPs__. High-resolution transmission electron microscope, dynamic light scattering, and zeta potential characterized __Ash C NPs__. Fourier transform infrared spectroscopy analyzed __Ash C NPs__, chitosan, and Ashwagandha root water extract. Moreover, the MTT assay evaluated the cytotoxicity of __Ash C NPs__ under the action of near-infrared light (NIR) irradiation. The MTT assay outcomes were statistically analyzed by Bonferroni post hoc multiple two-group comparisons using one-way variance analysis (ANOVA). Based on the Monte-Carlo simulation technique, the spatially resolved steady-state diffusely reflected light from the cancerous and healthy cells is acquired. The diffuse equation reconstructed the
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- Author
- Hala S. Abuelmakarem; Omnia Hamdy; Mahmoud A. Sliem; Jala El-Azab; Wafaa A. Ahmed
- Publisher
- Springer London
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)