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Pharmacokinetic Studies with Atenolol in the Dog by Dr. James McAinsh; Brian F. Holmes is a Medicine article available to read on EtoBox.

What is Pharmacokinetic Studies with Atenolol in the Dog about?

The pharmacokinetics of the cardioselective ,!hadrenoreceptor blocking agent atenolol have been determined following intravenous and oral dosing t o the dog. After intravenous administration at 200mg the blood levels of parent drug were found to decay tri-exponentially with a final elimination phase half-life of about 4.5 h. The volume of distribution for the central compartment was 40 per cent body weight and the whole body volume of distribution was 160 per cent body weight. The percentage urinary recovery of parent drug was 83 per cent. Following oral dosing at 400mg (as a solution and as a clinical trial tablet) the percentage urinary recovery was 65 per cent and the half-life extended slightly to between 5 and 6 h. The peak blood levels were however very similar for the two formulations (17 and 15 pg/ml for the solution and tablet respectively) and occurred at the same time (I-2h after dosing). The total areas under the blood concentration time curves were similar and the values (100 and 104pgml-'h respectively) agreed well with that anticipated on the basis of the intravenous data. It was concluded that the two formulations were bioequivalent and that following oral dosing at

Who reads Pharmacokinetic Studies with Atenolol in the Dog?

Author

Dr. James McAinsh; Brian F. Holmes

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0142-2782)

Published

1983

Language

EN

Field

Medicine (Health Sciences)