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The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients by Ji-Yoon Kim; Yeon-Sil Kim; Young-Kyoon Kim; Hyun-Jin Park; Seung-Joon Kim; Jin-Hyoung Kang; Young-Pil Wang; Hong-Seok Jang; Sang-Nam Lee; Sei-Chul Yoon is a Medicine article available to read on EtoBox.
What is The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients about?
## Background: The underlying molecular and cellular mechanisms of radiation pneumonitis (rp) are very complex. several biological factors need to be considered together with the well known dosimetric parameters for understanding the molecular events in developing rp in lung cancer patients. the aim of this study was to correlate the variations of the cytokine levels in lung cancer patients during radiation therapy (rt) with the occurrence of symptomatic rp. ## Methods: Thirty-four lung cancer patients who received three-dimensional conformal radiation therapy were evaluated prospectively. serial blood samples before, at the beginning, in the middle of, at the end of rt and 2 and 4 weeks after rt were analyzed for il-1alpha, il-6, il-10, tnf-alpha and tgf-beta1 by performing enzyme-linked immunosorbent assay. the predictive values of dosimetric factors for rp were evaluated, too. ## Results: Overall, 8 patients (23.5%) had grade >or= 2 rp. by serial measurement of cytokines level, only the tgf-beta1 level showed a correlation to the symptomatic rp. none of the other cytokines, il-1alpha, il-6, il-10 and tnf-alpha level was correlated with the risk of rp. the mean pretreatment tgf-b
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- Author
- Ji-Yoon Kim; Yeon-Sil Kim; Young-Kyoon Kim; Hyun-Jin Park; Seung-Joon Kim; Jin-Hyoung Kang; Young-Pil Wang; Hong-Seok Jang; Sang-Nam Lee; Sei-Chul Yoon
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2006-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1748-717X)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)