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Preparation of 5-Aryl-3-alkylthio-l,2,4-triazoles and Corresponding Sulfones with Antiinflammatory–analgesic Activity by Birsen Tozkoparan; Esra Küpeli; Erdem Yeşilada; Mevlüt Ertan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Preparation of 5-Aryl-3-alkylthio-l,2,4-triazoles and Corresponding Sulfones with Antiinflammatory–analgesic Activity about?
In this study, a series of 5-aryl-3-alkylthio-1,2,4-triazoles and corresponding sulfones were prepared with the objective of developing better analgesic-antiinflammatory compounds with minimum ulcerogenic risk. The structures of the compounds were elucidated by spectral and elemental analysis. The compounds were assayed per os in mice for their antiinflammatory and analgesic activity as well as the ulcerogenic risk and acute toxicity. Several of these compounds showed significant activity. Alkylsulfone derivatives were found to be much more potent analgesic-antiinflammatory agents than the corresponding alkylthio analogs. Compounds 9 and 11 were the most active of the series in both analgesic and antiinflammatory activity tests. In contrast to reference compound acetyl salicylic acid, these compounds did not induce gastric lesions in the stomach of experimental animals at the doses that exhibited analgesic/antiinflammatory activity.
Who reads Preparation of 5-Aryl-3-alkylthio-l,2,4-triazoles and Corresponding Sulfones with Antiinflammatory–analgesic Activity?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Birsen Tozkoparan; Esra Küpeli; Erdem Yeşilada; Mevlüt Ertan
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)