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A study of Streptococcus thermophilus proteome by integrated analytical procedures and differential expression investigations by Simona Arena; Chiara D'Ambrosio; Giovanni Renzone; Rosario Rullo; Luigi Ledda; Filomena Vitale; Giuseppe Maglione; Mario Varcamonti; Lino Ferrara; Andrea Scaloni is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract __Streptococcus thermophilus__ is a Gram‐positive bacterium belonging to the group of lactic acid bacteria, among which several genera play an essential role in manufacture of food products. Recently, a genomic consortium sequenced and annotated its entire genome, which has been demonstrated to contain 1900 coding sequences. In this study, we have revealed the expression products of almost 200 different genes using a proteomic strategy combining 2‐DE plus MALDI‐TOF PMF and differential 1‐DE plus μLC‐ESI‐IT‐MS/MS. Thus, a number of cellular pathways related to important physiological processes were described at the proteomic level. Almost 50 genes were related to multiple electrophoretic species, whose heterogeneity was mainly due to variability in p__I__ values. A 2‐DE reference map obtained for lactose‐grown cells was compared with those obtained after heat, cold, acid, oxidative and starvation stresses. Protein up/down‐regulation measurements demonstrated that adaptation to different environmental challenges may involve the contribution of unique as well as combined physiological mechanisms. Common regulatory sites in the promoter region of genes whose expression was
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It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Simona Arena; Chiara D'Ambrosio; Giovanni Renzone; Rosario Rullo; Luigi Ledda; Filomena Vitale; Giuseppe Maglione; Mario Varcamonti; Lino Ferrara; Andrea Scaloni
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 1615-9853)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)