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Diverging evolution of anti-GAD and anti-IA-2 antibodies in long-standing diabetes mellitus as a function of age at onset: no association with complications by Hermitte, L.; Atlan-Gepner, C.; Mattei, C.; Dufayet, D.; Jannot, M.F.; Christofilis, M.A.; Nervi, S.; Vialettes, B. is a Medicine article available to read on EtoBox.
What is Diverging evolution of anti-GAD and anti-IA-2 antibodies in long-standing diabetes mellitus as a function of age at onset: no association with complications about?
## Glutamic acid decarboxylase autoantibodies (GAD -A ) and tyrosine phosphatase IA-2 autoantibodies (IA2-A) were measured in sera of 50 recently diagnosed (Ͻ6 wk, 33 % younger than 15 yr), 19 short-term (1 to 9 yr, 35 % with onset age below 15 yr) and 89 long-standing diabetic patients (Ͼ10 yr, 57 % with onset age below 15 yr). Complications were assessed by clinical examination, retinal angiographs and microalbuminuria measurement. Both prevalences and levels of GAD-A and IA2-A decreased with increasing duration of diabetes. However even in those with long duration diabetes, 15 to 63 % of the sera were still positive for one or two antibodies. In the group with onset after the age of 15 yr, significantly higher prevalences and levels of GAD-A (but not IA2-A) was observed in comparison with the group with earlier onset. No association was found with any microvascular complications in any group. We conclude that GAD-A and IA2-A persist in some diabetic patients, despite a long duration. Persistence of GAD-A was greatest in those with postpubertal disease onset. We speculate that persistence of some beta-cells or specific environmental factors can sustain one autoimmune reaction esp
Who reads Diverging evolution of anti-GAD and anti-IA-2 antibodies in long-standing diabetes mellitus as a function of age at onset: no association with complications?
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- Author
- Hermitte, L.; Atlan-Gepner, C.; Mattei, C.; Dufayet, D.; Jannot, M.F.; Christofilis, M.A.; Nervi, S.; Vialettes, B.
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0742-3071)
- Published
- 1998
- Language
- EN
- Field
- Medicine (Health Sciences)