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Magnetization exchange with water and T ~1~relaxation of the downfield resonances in human brain spectra at 3.0 T: Exchange and T~1~Relaxation of Downfield Resonances by Erin L. MacMillan; Daniel G. Q. Chong; Wolfgang Dreher; Anke Henning; Chris Boesch; Roland Kreis is a Medicine article available to read on EtoBox.

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The use of water suppression for in vivo proton MR spectroscopy diminishes the signal intensities from resonances that undergo magnetization exchange with water, particularly those downfield of water. To investigate these exchangeable resonances, an inversion transfer experiment was performed using the metabolite cycling technique for non-watersuppressed MR spectroscopy from a large brain voxel in 11 healthy volunteers at 3.0 T. The exchange rates of the most prominent peaks downfield of water were found to range from 0.5 to 8.9 s 21 , while the T 1 relaxation times in absence of exchange were found to range from 175 to 525 ms. These findings may help toward the assignments of the downfield resonances and a better understanding of the sources of contrast in chemical exchange saturation transfer imaging.

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Author

Erin L. MacMillan; Daniel G. Q. Chong; Wolfgang Dreher; Anke Henning; Chris Boesch; Roland Kreis

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2011

Language

EN

Field

Medicine (Health Sciences)