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Can I read Adjunctive Cariprazine for the Treatment of Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study on EtoBox?
Adjunctive Cariprazine for the Treatment of Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study by Gary S. Sachs; Paul P. Yeung; Ludmyla Rekeda; Arifulla Khan; Julie L. Adams; Maurizio Fava is a Psychology article available to read on EtoBox.
What is Adjunctive Cariprazine for the Treatment of Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study about?
Objective: The purpose of this study was to investigate the efficacy of cariprazine, a dopamine D 3 -preferring D 3 /D 2 and serotonin 5-HT 1A receptor partial agonist, as adjunctive therapy for patients with major depressive disorder and nonresponse to at least one antidepressant monotherapy. Methods: In this double-blind placebo-controlled study, adults with major depressive disorder and inadequate response to antidepressants alone were randomized in a 1:1:1 ratio to placebo, cariprazine at 1.5 mg/day, or cariprazine at 3.0 mg/day. The primary outcome was change from baseline to week 6 in total score on the Montgomery-Åsberg Depression Rating Scale (MADRS). Least-squares mean differences were estimated in the modified intent-to-treat (mITT) population using a mixed-effects model for repeated measures with adjustment for multiple comparisons. ## Results: The mITT population comprised 751 patients (placebo: N5249; cariprazine 1.5 mg/day: N5250; cariprazine 3.0 mg/day: N5252). At week 6, the mean reduction from baseline in MADRS total score was significantly greater with cariprazine 1.5 mg/day than with placebo (214.1 vs. 211.5) but not with cariprazine 3.0 mg/day (213.1). Significa
Who reads Adjunctive Cariprazine for the Treatment of Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study?
It is typically read by researchers, students, and practitioners in Psychology.
- Author
- Gary S. Sachs; Paul P. Yeung; Ludmyla Rekeda; Arifulla Khan; Julie L. Adams; Maurizio Fava
- Publisher
- American Psychiatric Association Publishing
- Published
- 2023
- Language
- EN
- Field
- Psychology (Social Sciences)