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Psoriasis: a Focus on Upcoming Oral Formulations by Lluís Rusiñol; Elena Carmona-Rocha; Lluís Puig is a Medicine article available to read on EtoBox.

What is Psoriasis: a Focus on Upcoming Oral Formulations about?

## Introduc on: Targeted therapies have greatly improved the quality of life of pa ents with psoriasis. Despite the extensive list of treatments available, mul ple new drugs are being developed, especially oral therapies with poten al advantages as regards comfort of administra on. However, the efficacy and safety of these new oral therapies need to be improved to match those of novel biologics. ## Areas covered: We provide a narra ve review of the oral therapies for psoriasis that are currently under development, from Jak inhibitors to oral IL-17 and IL-23 inhibitors, among others. A literature search was performed for ar cles published from January 1, 2020, to June 6, 2023. ## Expert opinion: The approval of deucravaci nib, the first Jak inhibitor for the treatment of moderate-tosevere plaque psoriasis, heralds a bright therapeu c future with mul ple new oral formula ons. A great number of oral treatments with singular mechanism of ac on, like A3AR agonists, HSP90 inhibitors, ROCK-2 inhibitors, oral TNF inhibitors, oral IL-23 inhibitors, oral IL-17 inhibitors, PD4 inhibitors (orismilast) and several Tyk2 inhibitors, are currently being evaluated in clinical trials and could be su

Who reads Psoriasis: a Focus on Upcoming Oral Formulations?

Author

Lluís Rusiñol; Elena Carmona-Rocha; Lluís Puig

Publisher

Informa UK Limited

Published

2023

Language

EN

Field

Medicine (Health Sciences)