Can I read Novel Iron–polysaccharide Multilayered Microcapsules for Controlled Insulin Release on EtoBox?

Novel Iron–polysaccharide Multilayered Microcapsules for Controlled Insulin Release by Jian Zheng; Xiuli Yue; Zhifei Dai; Yang Wang; Shaoqin Liu; Xiufeng Yan is a Engineering article available to read on EtoBox.

What is Novel Iron–polysaccharide Multilayered Microcapsules for Controlled Insulin Release about?

Iron-polysaccharide complexes have been extensively used for the treatment of iron-deficiency anemia without side-effects. In this study, insulin-loaded microcapsules were prepared via layer-by-layer deposition of oppositely charged Fe(3+) and dextran sulfate (DS) onto the surface of insulin microparticles. Fe(3+) was combined with DS via both electrostatic interaction and chemical complexation process, leading to the formation of a stable complex of Fe(3+)/DS. Subsequently, protamine was used as the outermost layer of the insulin-loaded microcapsules to facilitate nuclear delivery. The sufficient charge reversal with successive deposition cycles and successful fabrication of hollow microcapsules provided strong evidence for the growth of (Fe(3+)/DS)(n) multilayer on the surface of microparticles. The experiments showed that the microcapsules successfully entrapped insulin with encapsulation efficiency of 70.56+/-0.97% and drug loading content of 46.15+/-0.97%. It was found that the release time and hypoglycemic effect increased as the number of deposited bilayers increased. The insulin-loaded microcapsules significantly improved glucose tolerance from 2 h (free insulin) to even 12

Who reads Novel Iron–polysaccharide Multilayered Microcapsules for Controlled Insulin Release?

Author

Jian Zheng; Xiuli Yue; Zhifei Dai; Yang Wang; Shaoqin Liu; Xiufeng Yan

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1742-7061)

Published

2009

Language

EN

Field

Engineering (Physical Sciences)