Can I read Lipid profile, plasma apolipoproteins, and pre-eclampsia risk in the GenPE case-control study on EtoBox?

Lipid profile, plasma apolipoproteins, and pre-eclampsia risk in the GenPE case-control study by Norma C. Serrano; Elizabeth Guio-Mahecha; Doris Cristina Quintero-Lesmes; Silvia Becerra- Bayona; María C. Paez; Mónica Beltran; Víctor M. Herrera; Lydia J. Leon; David Williams; Juan P. Casas is a Medicine article available to read on EtoBox.

What is Lipid profile, plasma apolipoproteins, and pre-eclampsia risk in the GenPE case-control study about?

## Background and aims: Pre-eclampsia constitutes a leading cause of maternal and perinatal morbidity and mortality. pre-eclampsia susceptibility is believed to be associated with altered lipid profiles and abnormal lipid metabolism via lipid peroxidation that leads to endothelial dysfunction. the goal of this study was to evaluate the association of maternal blood lipid and apolipoprotein levels with pre-eclampsia in a large-scale study. ## Methods: Using data from a large case-control study (1366 cases of pre-eclampsia and 1741 normotensive controls), the association between the distributions of eight lipid fractions and pre-eclampsia risk was evaluated using adjusted logistic regression models. pre-eclampsia was defined as blood pressure ≥140/90 mmhg and proteinuria ≥300 mg/24 h (>1 + dipstick). sub-group analyses were conducted for early (<34 weeks) and late (≥37 weeks) pre-eclampsia, estimating the effect of 1 standard deviation increase in log-transformed lipid fraction levels in adjusted multinomial regression models. ## Results: After adjustment for potential confounders, concentrations of triglycerides, apolipoprotein e (apoe) and the relationship between apolipoprotein b

Who reads Lipid profile, plasma apolipoproteins, and pre-eclampsia risk in the GenPE case-control study?

Author

Norma C. Serrano; Elizabeth Guio-Mahecha; Doris Cristina Quintero-Lesmes; Silvia Becerra- Bayona; María C. Paez; Mónica Beltran; Víctor M. Herrera; Lydia J. Leon; David Williams; Juan P. Casas

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0021-9150)

Published

2018

Language

EN

Field

Medicine (Health Sciences)