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Relationships of Sleep Disturbance, Intestinal Microbiota, and Postoperative Pain in Breast Cancer Patients: a Prospective Observational Study by Yao, Zhi-Wen; Zhao, Bing-Cheng; Yang, Xiao; Lei, Shao-Hui; Jiang, Yu-Mei; Liu, Ke-Xuan is a Medicine article available to read on EtoBox.
What is Relationships of Sleep Disturbance, Intestinal Microbiota, and Postoperative Pain in Breast Cancer Patients: a Prospective Observational Study about?
## Abstract ## Purpose Our study was designed to examine the possible relationship between gut microbiota, sleep disturbances, and acute postoperative pain. ## Methods Using 16S rRNA sequencing, we analyzed preoperative fecal samples from women undergoing breast cancer surgery. Preoperative sleep disturbance was evaluated with the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Peak and average pain at rest and movement were evaluated 24 h after surgery, using a numerical rating scale (NRS). Preoperative symptoms of depression and anxiety were assessed with the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7), respectively. Inflammation was measured using white blood cell and neutrophil counts, together with platelet-lymphocyte ratio, and neutrophil-lymphocyte ratio. ## Results Preoperative sleep disturbance was associated with more severe acute postoperative pain. At the phylum level, women with poor sleep quality had higher relative abundance of Firmicutes (p = 0.021) and lower relative abundance of Bacteroidetes (p = 0.013). At the genus level, women with poor sleep quality harbored higher relative abundance of Acidaminococcus and lower rela
Who reads Relationships of Sleep Disturbance, Intestinal Microbiota, and Postoperative Pain in Breast Cancer Patients: a Prospective Observational Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Yao, Zhi-Wen; Zhao, Bing-Cheng; Yang, Xiao; Lei, Shao-Hui; Jiang, Yu-Mei; Liu, Ke-Xuan
- Publisher
- Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1520-9512)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)