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Effectiveness of Collagen and Gatifloxacin in Improving the Healing and Antibacterial Activities of Gellan Gum Hydrogel Films as Dressing Materials by Aznatul Jannah Abu Bakar; Nurul Shahirah Mohd Azam; Vigneswari Sevakumaran; Wan Iryani Wan Ismail; Mohd Hasmizam Razali; Saiful Izwan Abdul Razak; Khairul Anuar Mat Amin is a Materials Science article available to read on EtoBox.
What is Effectiveness of Collagen and Gatifloxacin in Improving the Healing and Antibacterial Activities of Gellan Gum Hydrogel Films as Dressing Materials about?
The demand for advanced wound care products is rapidly increasing nowadays. In this study, gellan gum/collagen (GG/C) hydrogel films containing gatifloxacin (GAT) were developed to investigate their properties as wound dressing materials. ATR-FTIR, swelling, water content, water vapor transmission rate (WVTR), and thermal properties were investigated. The mechanical properties of the materials were tested in dry and wet conditions to understand the performance of the materials after exposure to wound exudate. Drug release by Franz diffusion was measured with all samples showing 100 % cumulative drug release after 40 min. Strong antibacterial activities against Staphylococcus aureus and Staphylococcus epidermis were observed for Gram-positive bacteria, while Escherichia coli and Pseudomonas aeruginosa were observed for Gram-negative bacteria. The in-vivo cytotoxicity of GG/C-GAT was assessed by wound contraction in rats, which was 95 % for GG/C-GAT01. Hematoxylin and eosin and Masson's trichrome staining revealed the appearance of fresh full epidermis and granulation tissue, indicating that all wounds had passed through the proliferation phase. The results demonstrate the promising
Who reads Effectiveness of Collagen and Gatifloxacin in Improving the Healing and Antibacterial Activities of Gellan Gum Hydrogel Films as Dressing Materials?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Aznatul Jannah Abu Bakar; Nurul Shahirah Mohd Azam; Vigneswari Sevakumaran; Wan Iryani Wan Ismail; Mohd Hasmizam Razali; Saiful Izwan Abdul Razak; Khairul Anuar Mat Amin
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Materials Science (Physical Sciences)