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Anoctamin/TMEM16 family members are Ca^2+^‐activated Cl^−^ channels by H. Criss Hartzell; Kuai Yu; Qinhuan Xiao; Li‐Ting Chien; Zhiqiang Qu is a Neuroscience article available to read on EtoBox.

What is Anoctamin/TMEM16 family members are Ca^2+^‐activated Cl^−^ channels about?

Ca^2+^‐activated Cl^−^ channels (CaCCs) perform many important functions in cell physiology including secretion of fluids from acinar cells of secretory glands, amplification of olfactory transduction, regulation of cardiac and neuronal excitability, mediation of the fast block to polyspermy in amphibian oocytes, and regulation of vascular tone. Although a number of proteins have been proposed to be responsible for CaCC currents, the anoctamin family (ANO, also known as TMEM16) exhibits characteristics most similar to those expected for the classical CaCC. Interestingly, this family of proteins has previously attracted the interest of both developmental and cancer biologists. Some members of this family are up‐regulated in a number of tumours and functional deficiency in others is linked to developmental defects.

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Author

H. Criss Hartzell; Kuai Yu; Qinhuan Xiao; Li‐Ting Chien; Zhiqiang Qu

Publisher

Cambridge University Press; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0022-3751)

Published

2009

Language

EN

Field

Neuroscience (Life Sciences)