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The study presents a multifunctional hydrogel designed to address chronic diabetic wound healing by disrupting the AGEs–RAGE–ROS cycle. This hydrogel combines manganese dioxide nanoparticles and quaternized chitosan, exhibiting antibacterial properties, reducing oxidative stress, and promoting angiogenesis, thus enhancing wound healing. In vitro and in vivo experiments confirm its effectiveness in mitigating inflammation and accelerating the healing process in chronic diabetic wounds.

Author

kashinath mahato

Language

EN