Can I read Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine on EtoBox?

Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine by Kwang Soon Kim; Sung-Wook Hong; Daehee Han; Jaeu Yi; Jisun Jung; Bo-Gie Yang; Jun Young Lee; Minji Lee; Charles D. Surh is a Medicine article available to read on EtoBox.

What is Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine about?

Dietary antigens are normally rendered nonimmunogenic through a poorly understood "oral tolerance" mechanism that involves immunosuppressive regulatory T (Treg) cells, especially Treg cells induced from conventional T cells in the periphery (pTreg cells). Although orally introducing nominal protein antigens is known to induce such pTreg cells, whether a typical diet induces a population of pTreg cells under normal conditions thus far has been unknown. By using germ-free mice raised and bred on an elemental diet devoid of dietary antigens, we demonstrated that under normal conditions, the vast majority of the small intestinal pTreg cells are induced by dietary antigens from solid foods. Moreover, these pTreg cells have a limited life span, are distinguishable from microbiota-induced pTreg cells, and repress underlying strong immunity to ingested protein antigens.

Who reads Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine?

Author

Kwang Soon Kim; Sung-Wook Hong; Daehee Han; Jaeu Yi; Jisun Jung; Bo-Gie Yang; Jun Young Lee; Minji Lee; Charles D. Surh

Published

2016

Language

EN

Field

Medicine (Social Sciences)