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Antibiotic resistance in patients with clinical features of healthcare-associated infections in an urban tertiary hospital in Sierra Leone: a cross-sectional study by Lakoh, Sulaiman; Li, Letian; Sevalie, Stephen; Guo, Xuejun; Adekanmbi, Olukemi; Yang, Guang; Adebayo, Oladimeji; Yi, Le; Coker, Joshua M.; Wang, Shuchao; Wang, Tiecheng; Sun, Weiyang; Habib, Abdulrazaq G.; Klein, Eili Y. is a Medicine article available to read on EtoBox.

What is Antibiotic resistance in patients with clinical features of healthcare-associated infections in an urban tertiary hospital in Sierra Leone: a cross-sectional study about?

## Background Available data on antibiotic resistance in sub-Saharan Africa is limited despite its increasing threat to global public health. As there is no previous study on antibiotic resistance in patients with clinical features of healthcare-associated infections (HAIs) in Sierra Leone, research is needed to inform public health policies. Our study aimed to assess antibiotic resistance rates from isolates in the urine and sputum samples of patients with clinical features of HAIs. ## Methodology We conducted a cross-sectional study of adult inpatients aged ≥18 years at Connaught Hospital, an urban tertiary care hospital in Freetown between February and June 2018. ## Results Over the course of the study, we enrolled 164 patients. Risk factors for HAIs were previous antibiotic use (93.3%), comorbidities (58.5%) and age (≥65 years) (23.9%). Of the 164 samples, 89.6% were urine. Bacterial growth was recorded in 58.8% of cultured specimens; the type of specimen was an independent predictor of bacterial growth (__p__ < 0.021). The most common isolates were __Escherichia coli__ and __Klebsiella pneumoniae__; 29.2% and 19.0% in urine samples and 18.8% and 31.3% in sputum samples, respec

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Author
Lakoh, Sulaiman; Li, Letian; Sevalie, Stephen; Guo, Xuejun; Adekanmbi, Olukemi; Yang, Guang; Adebayo, Oladimeji; Yi, Le; Coker, Joshua M.; Wang, Shuchao; Wang, Tiecheng; Sun, Weiyang; Habib, Abdulrazaq G.; Klein, Eili Y.
Publisher
BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central; Springer Science and Business Media LLC (ISSN 2047-2994)
Published
2020
Language
EN
Field
Medicine (Health Sciences)

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