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Plasma concentrations of tumor necrosis factor‐α (TNF‐α) and soluble TNF receptors in patients with bulimia nervosa by Yoshikatsu Nakai; Seiji Hamagaki; Ryuro Takagi; Ataru Taniguchi; Fumihiko Kurimoto is a Medicine article available to read on EtoBox.
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## BACKGROUND Tumor necrosis factor‐α (TNF‐α) is a cytokine with numerous immunological and metabolic activities. In addition, TNF‐α can stimulate a variety of physiological, neuroendocrine and behavioural responses of the central nervous system. In experimental animals, TNF‐α induces changes in physiological and behavioural parameters which have also been observed in eating disorders. The biological activities of TNF‐α are mediated by two structurally related, but functionally distinct receptors, TNF‐RI and TNF‐RII. Since injection of TNF‐α results in increased shedding of TNF‐α receptors, it is likely that TNF‐α release is reflected by soluble TNF‐receptors (sTNF‐Rs) levels. ## AIMS We studied plasma concentrations of TNF‐α and two sTNF‐Rs (sTNF‐RI and sTNF‐RII) in female patients with bulimia nervosa. ## DESIGN AND PATIENTS Twenty female patients with bulimia nervosa (BN) and 20 age‐matched normal women (N) were studied. ## MEASUREMENTS Plasma TNF‐α concentrations were measured by enzyme immunoassay kit and plasma concentrations of sTNF‐RI and sTNF‐RII were measured by enzyme‐linked immunosorbent assay. ## RESULTS Plasma TNF‐α concentrations in BN were significantly higher than
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- Author
- Yoshikatsu Nakai; Seiji Hamagaki; Ryuro Takagi; Ataru Taniguchi; Fumihiko Kurimoto
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)