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Detection of Both Herpes Simplex and Varicella-zoster Viruses in Cerebrospinal Fluid from Patients with Encephalitis by Casas, Inmaculada; Tenorio, Antonio; de Ory, Fernando; Lozano, Alvaro; Echevarría, José Manuel is a Medicine article available to read on EtoBox.
What is Detection of Both Herpes Simplex and Varicella-zoster Viruses in Cerebrospinal Fluid from Patients with Encephalitis about?
Cerebrospinal fluid (CSF) samples from 46 patients with encephalitis were studied f o r t h e presence of herpes simplex virus (HSV) types 1 and 2 and/or varicella zoster virus (VZV)-specific DNA sequences by the polymerase chain reaction (PCR) assay. Patients were studied because of detection of intrathecal production of IgG antibody t o HSV alone (10 patients, Group A) or t o both HSV and VZV ( 1 1 patients, Group B) or because of the presence of specific anti-HSV IgG in CSF without evidence of intrathecal antibody production (25 patients, Group C). CSF samples taken between days 1 and 10 f r o m onset of encephalitis were available f r o m all patients, and follow-up samples (taken after 10 days from onset) were obtained from some of them. Positive PCR results were obtained in a total of 13 patients. Four patients (three f r o m Group A and one f r o m Group B) gave amplification of HSV type 1 DNA alone, t w o patients (both from Group B) showed amplification of VZV DNA alone, and seven patients (all from Group B) gave dual amplification of both HSV type 1 and VZV DNA sequences in CSF. All CSF samples f r o m patients in Group C were negative by PCR. Ten patients with CSF sample
Who reads Detection of Both Herpes Simplex and Varicella-zoster Viruses in Cerebrospinal Fluid from Patients with Encephalitis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Casas, Inmaculada; Tenorio, Antonio; de Ory, Fernando; Lozano, Alvaro; Echevarría, José Manuel
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)