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## Abstract Metallic biomaterials implanted in a human body may corrode and wear, releasing metal ions and debris which may induce adverse reactions such as inflammation, allergy, neoplastic formation, developmental malformation, etc. Mutagenicity is a very fundamental and important toxicity related to carcinogenicity and reproductive/developmental toxicity because the damages to genes or DNA can be a cause of carcinogenesis and developmental abnormalities. However, available mutagenic data on metallic ions and compounds are restricted to the number of elements. Therefore, to obtain the systematic data necessary for metal ion mutagenicity, 41 metal salts encompassing 36 metals and 5 metallic elements tested with different valences, were evaluated on their mutagenicity by a microbial test, the __umu__ test. As a result, K~2~Cr~2~O~7~, RhCl~3~, IrCl~4~, and MgCl~2~ are positive without metabolic activation. Concentrations having the maximum mutagenic effect (__C__~max~) are 9.65 × 10^−5^, 1.00 × 10^−4^, 3.11 × 10^−3^, 4.12 × 10^−3^ mol · L^−1^, respectively. CuCl~2~, VCl~3~, CuCl, RhCl~3~, K~2~Cr~2~O~7~, and IrCl~4~ are positive with metabolic activation by S‐9 mix with __C__~max~ of

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Author

Akiko Yamamoto; Yuko Kohyama; Takao Hanawa

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

2001

Language

EN

Field

Medicine (Health Sciences)