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Efficacy and Safety of Gefapixant for Chronic Cough: a Meta-analysis of Randomised Controlled Trials by Min-Hsiang Chuang; I-Wen Chen; Jen-Yin Chen; Fu-Chi Kang; Chun-Ning Ho; Shao-Chun Wu; Ming Yew; Kuo-Mao Lan; Kuo-Chuan Hung is a Medicine article available to read on EtoBox.
What is Efficacy and Safety of Gefapixant for Chronic Cough: a Meta-analysis of Randomised Controlled Trials about?
## Background The efficacy and safety of gefapixant in adults with chronic cough remain unclear. Our objective was to assess the efficacy and safety of gefapixant using updated evidence. ## Methods MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL) and Embase databases were searched from inception through September 2022. Subgroup analysis based on dose of gefapixant (__i.e.__ ≤20, 45–50 and ≥100 mg twice daily for low, moderate and high doses, respectively) was performed to explore a potential dose-dependent effect. ## Results Five studies involving seven trials showed the efficacy of moderate- or high-dose gefapixant for reducing objective 24-h cough frequency (estimated relative reduction 30.9% and 58.5%, respectively) (__i.e.__ primary outcome) and awake cough frequency (estimated relative reduction 47.3% and 62.8%, respectively). Night-time cough frequency was only reduced with high-dose gefapixant. Consistently, the use of moderate- or high-dose gefapixant significantly alleviated cough severity and improved cough-related quality of life, but increased the risk of all-cause adverse events (AEs), treatment-related AEs and ageusia/dysgeusia/hypogeusia. Subgroup an
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- Author
- Min-Hsiang Chuang; I-Wen Chen; Jen-Yin Chen; Fu-Chi Kang; Chun-Ning Ho; Shao-Chun Wu; Ming Yew; Kuo-Mao Lan; Kuo-Chuan Hung
- Publisher
- European Respiratory Society (ERS)
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)