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What is Protein Folding Mechanisms in Cells about?

HSP70, chaperonins like GroEL/ES, and HSP90 are molecular chaperones that assist protein folding in cells. HSP70 binds substrates when ATP-bound and releases them when ADP-bound. GroEL encapsulates substrates within its cavity when the apical domains are in the ATP-bound up position. HSP90 binds substrates in its nucleotide-free state and closes upon ATP binding to aid folding. Co-chaperones regulate the ATPase cycles and substrate transfer between chaperones. The heat shock response upregulates chaperone e

Author

VanessaPenguin

Language

EN