Opening book details…
Can I read Thrombopoietin Serum Levels in Patients with Aplastic Anaemia: Correlation with Platelet Count and Persistent Elevation in Remission on EtoBox?
Thrombopoietin Serum Levels in Patients with Aplastic Anaemia: Correlation with Platelet Count and Persistent Elevation in Remission by Hubert Schrezenmeier; Martin Griesshammer; Alex Hornkohl; Janet L. Nichol; Thomas Hecht; Herrmann Heimpel; Bernhard Kubanek; Aruna Raghavachar is a Medicine article available to read on EtoBox.
What is Thrombopoietin Serum Levels in Patients with Aplastic Anaemia: Correlation with Platelet Count and Persistent Elevation in Remission about?
In an attempt to evaluate the role of thrombopoietin (TPO) in the pathobiology of aplastic anaemia (AA), we have examined TPO levels in sera from 54 AA patients and 119 healthy controls. A total of 92 samples were collected from AA patients: 43 samples were harvested at diagnosis, 23 samples in the cytopenic period after treatment, and 26 samples when patients were in partial (__n__ = 10) or complete remission (__n__ = 16) following immunosuppressive treatment. TPO serum levels were assessed by a sandwich‐antibody ELISA that utilized a polyclonal rabbit antiserum for both capture and signal. Serum samples from normal donors revealed a mean TPO level of 95.3 ± 54.0 pg/ml (standard deviation). Mean TPO levels in AA sera collected at diagnosis and before onset of treatment were 2728 ± 1074 pg/ml (__P__ < 0.001 compared to normal controls; mean platelet count at that time: 27 × 10^9^/l). TPO serum levels of AA patients in partial or complete remission after immunosuppressive treatment were significantly lower than TPO levels at diagnosis (__P__ < 0.001). However, despite normal platelet counts (mean 167 × 10^9^/l), TPO levels remained significantly elevated in complete remission (mean
Who reads Thrombopoietin Serum Levels in Patients with Aplastic Anaemia: Correlation with Platelet Count and Persistent Elevation in Remission?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hubert Schrezenmeier; Martin Griesshammer; Alex Hornkohl; Janet L. Nichol; Thomas Hecht; Herrmann Heimpel; Bernhard Kubanek; Aruna Raghavachar
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 1998
- Language
- EN
- Field
- Medicine (Health Sciences)