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Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source by Susan M. McKiernan; Richard Hagan; Michael Curry; George S. A. McDonald; Alan Kelly; Niamh Nolan; Anne Walsh; John Hegarty; Emer Lawlor; Dermot Kelleher is a Medicine article available to read on EtoBox.

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The role of cytotoxic T lymphocyte responses, restricted by human leukocyte antigen (HLA) class I alleles, is recognized as highly significant in the successful clearance of hepatitis C virus (HCV). The frequency of class I alleles in females inoculated with HCV genotype 1b from a single source was examined for an association with outcome. Class I typing was performed using polymerase chain reaction sequence-specific primers in 227 female subjects: 141 had chronic infection and 86 had viral clearance. Statistical analysis included 2 testing and multiple logistic regression analysis. A\*03, B\*27, and Cw\*01 occurred more frequently in those with viral clearance (39.5%, 14%, and 9.3%, respectively) compared with those with chronic infection (19.1%, 2.1%, and 1.4%, respectively; P < .005). B\*08 occurred more often in those with chronic infection compared with viral clearance (39.7% vs. 19.8%; P ‫؍‬ .002). In combination with previously reported class II allele associations, over 75% that successfully eliminate HCV carry either A\*03, DRB1\*0101, or \*0401, compared with only 37% of those with chronic infection (P < .0001). The haplotypes A\*03-B\*07-DRB1\*15-DQB1\*0602 and A\*02-B\*

Who reads Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source?

Author

Susan M. McKiernan; Richard Hagan; Michael Curry; George S. A. McDonald; Alan Kelly; Niamh Nolan; Anne Walsh; John Hegarty; Emer Lawlor; Dermot Kelleher

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2004

Language

EN

Field

Medicine (Health Sciences)