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A Multi-laboratory Preclinical Trial in Rodents to Assess Treatment Candidates for Acute Ischemic Stroke by Patrick D. Lyden; Márcio A. Diniz; Francesca Bosetti; Jessica Lamb; Karisma A. Nagarkatti; André Rogatko; Sungjin Kim; Ryan P. Cabeen; James I. Koenig; Kazi Akhter; Ali S. Arbab; Brooklyn D. Avery; Hannah E. Beatty; Adnan Bibic; Suyi Cao; Ligia Simoes Braga Boisserand; Angel Chamorro; Anjali Chauhan; Sebastian Diaz-Perez; Krishnan Dhandapani; Nirav Dhanesha; Andrew Goh; Alison L. Herman; Fahmeed Hyder; Takahiko Imai; Conor W. Johnson; Mohammad B. Khan; Pradip Kamat; Senthilkumar S. Karuppagounder; Mariia Kumskova; Jelena M. Mihailovic; Joseph B. Mandeville; Andreia Morais; Rakesh B. Patel; Basavaraju G. Sanganahalli; Cameron Smith; Yanrong Shi; Brijesh Sutariya; Daniel Thedens; Tao Qin; Sofia E. Velazquez; Jaroslaw Aronowski; Cenk Ayata; Anil K. Chauhan; Enrique C. Leira; David C. Hess; Raymond C. Koehler; Louise D. McCullough; Lauren H. Sansing is a Medicine article available to read on EtoBox.
What is A Multi-laboratory Preclinical Trial in Rodents to Assess Treatment Candidates for Acute Ischemic Stroke about?
Human diseases may be modeled in animals to allow preclinical assessment of putative new clinical interventions. Recent, highly publicized failures of large clinical trials called into question the rigor, design, and value of preclinical assessment. We established the Stroke Preclinical Assessment Network (SPAN) to design and implement a randomized, controlled, blinded, multi-laboratory trial for the rigorous assessment of candidate stroke treatments combined with intravascular thrombectomy. Efficacy and futility boundaries in a multi-arm multi-stage statistical design aimed to exclude from further study highly effective or futile interventions after each of four sequential stages. Six independent research laboratories performed a standard focal cerebral ischemic insult in five animal models that included equal numbers of males and females: young mice, young rats, aging mice, mice with diet-induced obesity, and spontaneously hypertensive rats. The laboratories adhered to a common protocol and efficiently enrolled 2615 animals with full data completion and comprehensive animal tracking. SPAN successfully implemented treatment masking, randomization, prerandomization inclusion and ex
Who reads A Multi-laboratory Preclinical Trial in Rodents to Assess Treatment Candidates for Acute Ischemic Stroke?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Patrick D. Lyden; Márcio A. Diniz; Francesca Bosetti; Jessica Lamb; Karisma A. Nagarkatti; André Rogatko; Sungjin Kim; Ryan P. Cabeen; James I. Koenig; Kazi Akhter; Ali S. Arbab; Brooklyn D. Avery; Hannah E. Beatty; Adnan Bibic; Suyi Cao; Ligia Simoes Braga Boisserand; Angel Chamorro; Anjali Chauhan; Sebastian Diaz-Perez; Krishnan Dhandapani; Nirav Dhanesha; Andrew Goh; Alison L. Herman; Fahmeed Hyder; Takahiko Imai; Conor W. Johnson; Mohammad B. Khan; Pradip Kamat; Senthilkumar S. Karuppagounder; Mariia Kumskova; Jelena M. Mihailovic; Joseph B. Mandeville; Andreia Morais; Rakesh B. Patel; Basavaraju G. Sanganahalli; Cameron Smith; Yanrong Shi; Brijesh Sutariya; Daniel Thedens; Tao Qin; Sofia E. Velazquez; Jaroslaw Aronowski; Cenk Ayata; Anil K. Chauhan; Enrique C. Leira; David C. Hess; Raymond C. Koehler; Louise D. McCullough; Lauren H. Sansing
- Publisher
- American Association for the Advancement of Science (AAAS)
- Published
- 2023
- Language
- EN
- Field
- Medicine (Life Sciences)