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Bacterial Analysis Using an Electrochemical DNA Biosensor with Poly-Adenine-Mediated DNA Self-Assembly by Lanying Li; Lele Wang; Qin Xu; Li Xu; Wen Liang; Yan Li; Min Ding; Ali Aldalbahi; Zhilei Ge; Lihua Wang; Juan Yan; Na Lu; Jiang Li; Yanli Wen; Gang Liu is a Engineering article available to read on EtoBox.
What is Bacterial Analysis Using an Electrochemical DNA Biosensor with Poly-Adenine-Mediated DNA Self-Assembly about?
Recently, consecutive adenines (polyA) have been exploited to assemble oligonucleotides on the gold surface with a high affinity comparable to Au-S chemistry [36][37][38][39][40][41] . Pei et al. reported a polyA-mediated strategy for DNA assembly on gold nanoparticles (AuNPs) with precise amount regulation and well organized upright conformation 42 . Later, near-unity yields of nanoparticles with fixed valences or even monovalence were obtained by tuning the length of polyA 11 , indicating the strong controllability of the DNA arrangements on the gold surface. Since then, the polyA-AuNP assembly strategy has been successfully adopted in biosensors targeting DNAs 40,43 and microRNAs [44][45] , or in applications for intracellular delivery of functional nucleic acids 46 . However, when applied to electrochemical platform, the poor electron transfer efficiency of the pure polyA SAM seriously hindered the signal-to-noise ratio (S/N) of the electrochemical biosensor. To develop a polyA-based electrochemical interface, in this work, we designed a novel polyA-based capture probe (polyA-P) consist of a recognition part and a polyA anchoring block, tword a sensitive "sandwich-type" electro
Who reads Bacterial Analysis Using an Electrochemical DNA Biosensor with Poly-Adenine-Mediated DNA Self-Assembly?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Lanying Li; Lele Wang; Qin Xu; Li Xu; Wen Liang; Yan Li; Min Ding; Ali Aldalbahi; Zhilei Ge; Lihua Wang; Juan Yan; Na Lu; Jiang Li; Yanli Wen; Gang Liu
- Publisher
- American Chemical Society (ACS)
- Published
- 2018
- Language
- EN
- Field
- Engineering (Physical Sciences)