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Can I read ERBB2, TBX2, RPS6KB1, and MYC alterations in breast tissues of BRCA1 and BRCA2 mutation carriers on EtoBox?
ERBB2, TBX2, RPS6KB1, and MYC alterations in breast tissues of BRCA1 and BRCA2 mutation carriers by Camilo Adem; Cheryl L. Soderberg; Kari Hafner; Carol Reynolds; Jeffrey M. Slezak; Colleen S. Sinclair; Thomas A. Sellers; Daniel J. Schaid; Fergus Couch; Lynn C. Hartmann; Robert B. Jenkins is a Medicine article available to read on EtoBox.
What is ERBB2, TBX2, RPS6KB1, and MYC alterations in breast tissues of BRCA1 and BRCA2 mutation carriers about?
Breast cancer risk is greatly increased in women who carry mutations in the BRCA1 or BRCA2 genes. Because breast cancer initiation is different between BRCA1/2 mutation carriers and women who do not carry mutations, it is possible that the mechanism of breast cancer progression is also different. Histopathologic and genetic studies have supported this hypothesis. To test this hypothesis further, we utilized a large cohort of women who underwent therapeutic mastectomy (TM) and contralateral prophylactic mastectomy (PM). From this cohort, we developed case groups of women with a family history of breast cancer with BRCA1/2 deleterious mutations, with unclassified variant alterations, and with no detected mutation and matched these cases with sporadic controls from the same TM and PM cohort. Fluorescence in situ hybridization was performed on paraffin sections by use of dual-color probes for ERBB2/CEP17, MYC/CEP8, TBX2/CEP17, and RPS6KB1/CEP17. All malignant and benign lesions, including putative precursor lesions, were studied. The invasive cancers from deleterious mutation carriers had a higher prevalence of duplication of MYC (P = 0.006) and TBX2 (P = 0.0008) compared to controls a
Who reads ERBB2, TBX2, RPS6KB1, and MYC alterations in breast tissues of BRCA1 and BRCA2 mutation carriers?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Camilo Adem; Cheryl L. Soderberg; Kari Hafner; Carol Reynolds; Jeffrey M. Slezak; Colleen S. Sinclair; Thomas A. Sellers; Daniel J. Schaid; Fergus Couch; Lynn C. Hartmann; Robert B. Jenkins
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Life Sciences)