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Can I read Altered Opioid-mediated Control of the Spinal Release of Dynorphin and Met-enkephalin in Polyarthritic Rats on EtoBox?
Altered Opioid-mediated Control of the Spinal Release of Dynorphin and Met-enkephalin in Polyarthritic Rats by Sébastien Ballet; Annie Mauborgne; Michel Hamon; François Cesselin; Elisabeth Collin is a Neuroscience article available to read on EtoBox.
What is Altered Opioid-mediated Control of the Spinal Release of Dynorphin and Met-enkephalin in Polyarthritic Rats about?
Previous studies showed that spinal opioidergic neurotransmission is markedly altered in the polyarthritic rat, a model of chronic inflammatory pain. Present investigations aimed at assessing possible changes in opioid-mediated control of the spinal outflow of met-enkephalin (ME) and dynorphin (DYN) in these animals. Intrathecal (i.t.) perfusion under halothane anesthesia showed that polyarthritis was associated with both a 40% decrease in the spinal outflow of ME-like material (MELM) and a 90% increase in that of DYNLM. Local treatment with the -opioid agonist DAGO (10 M i.t.) inhibited equally (-30%) the MELM outflow in polyarthritic and control rats, whereas the ␦ agonist DTLET (10 M i.t.) also reduced the peptide outflow in controls (-27%) but enhanced it in polyarthritic animals (ϩ56%). On the other hand, both DAGO (10 M i.t.) and DTLET (10 M i.t.) decreased (-40 and -49%) DYNLM outflow in polyarthritic rats, but were inactive in controls. Finally, neither MELM outflow nor that of DYNLM were affected by the -agonist U50488H (10 M i.t.) in both groups of rats. In all cases, the changes due to active agonists could be prevented by specific antagonists which were inactive on thei
Who reads Altered Opioid-mediated Control of the Spinal Release of Dynorphin and Met-enkephalin in Polyarthritic Rats?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Sébastien Ballet; Annie Mauborgne; Michel Hamon; François Cesselin; Elisabeth Collin
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)
- Published
- 2000
- Language
- EN
- Field
- Neuroscience (Life Sciences)