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Metformin Add-on Continuous Subcutaneous Insulin Infusion on Precise Insulin Doses in Patients with Type 2 Diabetes by Li, Feng-fei; Liu, Bing-li; Yin, Guo-ping; Yan, Reng-na; Zhang, Dan-feng; Wu, Jin-dan; Ye, Lei; Su, Xiao-fei; Ma, Jian-hua is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Metformin Add-on Continuous Subcutaneous Insulin Infusion on Precise Insulin Doses in Patients with Type 2 Diabetes about?
To investigate whether metformin add-on to the continuous subcutaneous insulin infusion (Met + CSII) therapy leads to a significant reduction in insulin doses required by type 2 diabetes (T2D) patients to maintain glycemic control, and an improvement in glycemic variation (GV) compared to CSII only therapy. We analyzed data from our two randomized, controlled open-label trials. Newly diagnoses T2D patients were randomized assigned to receive either CSII therapy or Met + CSII therapy for 4 weeks. Subjects were subjected to a 4-day continuous glucose monitoring (CGM) at the endpoint. Insulin doses and GV profiles were analyzed. The primary endpoint was differences in insulin doses and GV between the two groups. A total of 188 subjects were admitted as inpatients. Subjects in metformin add-on therapy required significantly lower total, basal and bolus insulin doses than those of control group. CGM data showed that patients in Met + CSII group exhibited significant reduction in the 24-hr mean amplitude of glycemic excursions (MAGE), the standard deviation, and the coefficient of variation compared to those of control group. Our data suggest that metformin add-on to CSII therapy leads t
Who reads Metformin Add-on Continuous Subcutaneous Insulin Infusion on Precise Insulin Doses in Patients with Type 2 Diabetes?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Li, Feng-fei; Liu, Bing-li; Yin, Guo-ping; Yan, Reng-na; Zhang, Dan-feng; Wu, Jin-dan; Ye, Lei; Su, Xiao-fei; Ma, Jian-hua
- Publisher
- Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)