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Prime Vaccination with Chitosan-Coated Phipps BCG and Boosting with CFP-PLGA against Tuberculosis in a Goat Model by Contreras-Magallanes, Yesenia Guadalupe (author);Durán-Aguilar, Marina (author);Sosa-Gallegos, Susana L. (author);Álvarez, Ángel H. (author);Andrade-Santillán, Fátima A. (author);Bárcenas-Reyes, Isabel (author);González-Ruíz, Sara (author);Rodríguez-Hernández, Elba (author);Cantó-Alarcón, Germinal J. (author);Milián-Suazo, Feliciano (author) is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Prime Vaccination with Chitosan-Coated Phipps BCG and Boosting with CFP-PLGA against Tuberculosis in a Goat Model about?

## Simple Summary Bovine tuberculosis is a disease that affects cattle and other animal species worldwide and represents a risk to public health. Even though there is a vaccine that has been used to control tuberculosis in humans for almost 100 years, up to now, it has not been used in animals. The reason is that vaccination interferes with the tuberculin test, the current test to diagnose tuberculosis in the field, and shows an inconsistent efficacy in animals. Recent studies report that prime vaccinating with BCG and boosting with proteins vaccinations perform better. In addition, there are reports that some polymers increase the immune response against various infectious diseases; therefore, testing a vaccine formula with polymers sounds like a wise thing to do. In this study, we showed that priming with BCG and boosting with a culture filtrate protein, alone or in combination with a polymer, the number of animals with lesions, the number of lesions per animal, and the size of the lesions in vaccinated animals, compared with those not vaccinated or those vaccinated with BCG alone, are significantly reduced. Our results mean that a vaccination used as a complement of actual tuber

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Author

Contreras-Magallanes, Yesenia Guadalupe (author);Durán-Aguilar, Marina (author);Sosa-Gallegos, Susana L. (author);Álvarez, Ángel H. (author);Andrade-Santillán, Fátima A. (author);Bárcenas-Reyes, Isabel (author);González-Ruíz, Sara (author);Rodríguez-Hernández, Elba (author);Cantó-Alarcón, Germinal J. (author);Milián-Suazo, Feliciano (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)