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Influence of Sulfate and Carboxylate Groups on the Conformation of Chondroitin Sulfate Related Disaccharides by Marianne Zsiška; Bernd Meyer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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1H NMR and 13C NMR spectral parameters of eight sulfated uronic acid containing disaccharides 1-8 were used to determine the conformational preferences that depend on the pattern of sulfation. Three sulfated derivatives of benzyl beta-D-Gal-(1-->4)-beta-D-GlcA (1), its 6'-sulfate 2, 4'-sulfate 3, and 4',6'-disulfate 4 were used as models for the beta-(1-->4) glycosidic linkage of chondroitin sulfates and three sulfated derivatives of benzyl beta-D-GlcA-(1-->3)-beta-D-Gal (5), its 6-sulfate 6, 4-sulfate 7, and 4,6-disulfate 8 were used as models for the beta-(1-->3) glycosidic linkage of chondroitin sulfates. To determine the dependence of conformational preferences on the charged groups, the sulfated disaccharides 2, 3, and 4 were compared to their unsulfated parent compound 1, and 6, 7, and 8 were compared to their parent compound 5. The 3JH-5,H-6 coupling constants were determined by high-order analysis of the spin systems, and from these the preferred populations of the hydroxymethyl groups were calculated. Selective 1D NOEs and ROEs were measured from H-1' across the glycosidic linkage to obtain the average distance of the protons adjacent to the glycosidic linkage. Derivatives

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Author

Marianne Zsiška; Bernd Meyer

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0008-6215)

Published

1993

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)