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Head region of unconventional myosin I family members is responsible for the organ‐specificity of their roles in left–right polarity in \ \ Drosophila\ \ by Shunya Hozumi; Reo Maeda; Maiko Taniguchi‐Kanai; Takashi Okumura; Kiichiro Taniguchi; Yasuhiro Kawakatsu; Naotaka Nakazawa; Ryo Hatori; Kenji Matsuno is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Head region of unconventional myosin I family members is responsible for the organ‐specificity of their roles in left–right polarity in \ \ Drosophila\ \ about?

## Abstract In __Drosophila__, __Myosin31DF__ (__Myo31DF__), encoding a Myosin ID protein, has crucial roles in left–right (LR) asymmetric development. Loss of __Myo31DF__ function leads to laterality inversion for many organs, including the embryonic gut. Here, we found that __Myo31DF__ was required before LR asymmetric morphogenesis in the hindgut, suggesting it functions in LR patterning instead of directly in hindgut morphological changes. __Myosin61F__ (__Myo61F__) encodes another Myosin I, and Myo31DF or Myo61F overexpression reverses the laterality of different organs. Myo31DF and Myo61F have domains conserved in Myosin proteins, particularly in the proteins' head regions. We studied the roles of these domains in LR patterning using overexpression analysis. The Actin‐binding and ATP‐binding domains were essential for both proteins, but the IQ domains, binding sites for Myosin light chains, were required only by Myo31DF. Our results also suggest that the organ specificities of the Myo31DF and Myo61F activities depended on their head regions. Developmental Dynamics 237:3528–3537, 2008. © 2008 Wiley‐Liss, Inc.

Who reads Head region of unconventional myosin I family members is responsible for the organ‐specificity of their roles in left–right polarity in \ \ Drosophila\ \?

Author

Shunya Hozumi; Reo Maeda; Maiko Taniguchi‐Kanai; Takashi Okumura; Kiichiro Taniguchi; Yasuhiro Kawakatsu; Naotaka Nakazawa; Ryo Hatori; Kenji Matsuno

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1058-8388)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)