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Role of Extracellular Signal‐regulated Kinase in the Ventral Tegmental Area in the Suppression of the Morphine‐induced Rewarding Effect in Mice with Sciatic Nerve Ligation by Satoru Ozaki; Minoru Narita; Michiko Narita; Masahiko Ozaki; Junaidi Khotib; Tsutomu Suzuki is a Neuroscience article available to read on EtoBox.
What is Role of Extracellular Signal‐regulated Kinase in the Ventral Tegmental Area in the Suppression of the Morphine‐induced Rewarding Effect in Mice with Sciatic Nerve Ligation about?
## Abstract We recently reported that μ‐opioid receptor agonist morphine failed to induce its rewarding effects in rodents with sciatic nerve injury. In the present study, we investigated whether a state of neuropathic pain induced by sciatic nerve ligation could change the activities of the extracellular signal‐regulated kinase (ERK) and p38 in the mouse lower midbrain area including the ventral tegmental area (VTA), and these changes could directly affect the development of the morphine‐induced rewarding effect in mice. The sciatic nerve ligation caused a long‐lasting and profound thermal hyperalgesia. A dose‐dependent place preference induced by s.c. administration of morphine was observed in sham‐operated mice, but not in sciatic nerve‐ligated mice. We found here for the first time that nerve injury produces a sustained and significant reduction in protein levels of phosphorylated‐ERK and ‐p38 in cytosolic preparations of the mouse lower midbrain. The inhibition of ERK activity by i.c.v. pre‐treatment with either PD98059 or U0126 impaired the morphine‐induced place preference. In contrast, i.c.v. treatment with a specific inhibitor of p38, SB203580, did not interfere with the m
Who reads Role of Extracellular Signal‐regulated Kinase in the Ventral Tegmental Area in the Suppression of the Morphine‐induced Rewarding Effect in Mice with Sciatic Nerve Ligation?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Satoru Ozaki; Minoru Narita; Michiko Narita; Masahiko Ozaki; Junaidi Khotib; Tsutomu Suzuki
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 2004
- Language
- EN
- Field
- Neuroscience (Life Sciences)