About this Medicine article
Kinetics of Inflammatory Cytokines in Patients with Scrub Typhus Receiving Doxycycline Treatment by Doo Ryeon Chung; Young Seok Lee; Seung Soon Lee is a Medicine article available to read on EtoBox.
## Objectives: Animal models have suggested that various cytokines and chemokines play an important role in host defense against orientia tsutsugamushi, however, human data are limited. we investigated the kinetics of inflammatory responses in patients with scrub typhus receiving doxycycline. ## Methods: Amongst patients being treated for scrub typhus, serially collected sera were tested for tnf-alpha, ifn-gamma, il-2, il-4, il-5, and il-10 by immunoassay. the mrnas encoding tnf-alpha, il-1 beta, il-6, il-8, ifn-gamma, il-12, il-2, il-4, il-5, and il-10 were measured by semiquantitative reverse transcription-pcr. ## Results: The concentrations of tnf-alpha, ifn-gamma, and il-10 of patients prior to doxycycline treatment were significantly higher than those of healthy volunteers. they decreased markedly within 24h after starting doxycycline. the mrnas for il-1 beta, tnf-alpha, il-6, ifn-gamma, and il-10 were highly expressed. expression of mrnas for il-1 beta, ifn-gamma, and il-10 decreased at day 2-7 of doxycycline treatment. ## Conclusions: Inflammatory cytokines including tnf-alpha, il-1 beta, and il-6 are markedly upregulated in patients with scrub typhus. doxycycline treatment
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- Author
- Doo Ryeon Chung; Young Seok Lee; Seung Soon Lee
- Publisher
- Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 0163-4453)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)