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Evaluation of Single and Multiple Hyaluronic Acid Injections at Different Concentrations with High Molecular Weight in the Treatment of Knee Osteoarthritis by Selim Safali; Erkan Sabri Ertaş; Ali Özdemir; Deniz Cataklı is a Medicine article available to read on EtoBox.
What is Evaluation of Single and Multiple Hyaluronic Acid Injections at Different Concentrations with High Molecular Weight in the Treatment of Knee Osteoarthritis about?
## Background Knee osteoarthritis is severe progressive and most commonly diagnosed articular disease and its incidence is increasing around the world depending on age. This pathologic condition which limits daily activity of patients can be characterized by degeneration of cartilage and inflammation. Although non-steroidal anti-inflammatory (NSAII) agents and other analgesics are routinely used treatment options, the potential effects of intraarticular injections including hyaluronic acid (HA) have also been demonstrated by various studies. However, few studies compare the efficacy of a single high molecular weight (HMW) high dose and a triple HMW low dose. This study aimed to compare the efficacy of single high molecular weight (HMW) high dose (2 mL / 60 mg) and triple HMW low dose (2 mL /30 mg) intra-articular injection of HA in knee osteoarthritis (OA) patients by evaluating function and pain parameters during 12 months. ## Methods This is a single-center, retrospective clinical study that included and involved 128 patients. Group I (__n__=64) patients received triple 30 mg HA injections (SEMICAL®) with one-week intervals, while Group II (__n__=64) patients received a single 60
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- Author
- Selim Safali; Erkan Sabri Ertaş; Ali Özdemir; Deniz Cataklı
- Publisher
- BioMed Central
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)