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Association Between Molecular Subtypes of Colorectal Tumors and Patient Survival, Based on Pooled Analysis of 7 International Studies by Amanda I. Phipps; Elizabeth Alwers; Tabitha Harrison; Barbara Banbury; Hermann Brenner; Peter T. Campbell; Jenny Chang-Claude; Daniel Buchanan; Andrew T. Chan; Alton B. Farris; Jane C. Figueiredo; Steven Gallinger; Graham G. Giles; Mark Jenkins; Roger L. Milne; Polly A. Newcomb; Martha L. Slattery; Mingyang Song; Shuji Ogino; Syed H. Zaidi; Michael Hoffmeister; Ulrike Peters is a Medicine article available to read on EtoBox.
What is Association Between Molecular Subtypes of Colorectal Tumors and Patient Survival, Based on Pooled Analysis of 7 International Studies about?
## Background and aims: The heterogeneity among colorectal tumors is probably due to differences in developmental pathways and might associate with patient survival times. we studied the relationship among markers of different subtypes of colorectal tumors and patient survival. ## Methods: We pooled data from 7 observational studies, comprising 5010 patients with colorectal cancer. all the studies collected information on microsatellite instability (msi), cpg island methylator phenotype (cimp), and mutations in kras and braf in tumors. tumors with complete marker data were classified as type 1 (msi-high, cimp-positive, with pathogenic mutations in braf but not kras), type 2 (not msi-high, cimp-positive, with pathogenic mutations in braf but not kras), type 3 (not msi-high or cimp, with pathogenic mutations in kras but not braf), type 4 (not msi-high or cimp, no pathogenic mutations in braf or kras), or type 5 (msi-high, no cimp, no pathogenic mutations in braf or kras). we used cox regression to estimate hazard ratios (hr) and 95% confidence intervals (cis) for associations of these subtypes and tumor markers with disease-specific survival (dss) and overall survival times, adjustin
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- Author
- Amanda I. Phipps; Elizabeth Alwers; Tabitha Harrison; Barbara Banbury; Hermann Brenner; Peter T. Campbell; Jenny Chang-Claude; Daniel Buchanan; Andrew T. Chan; Alton B. Farris; Jane C. Figueiredo; Steven Gallinger; Graham G. Giles; Mark Jenkins; Roger L. Milne; Polly A. Newcomb; Martha L. Slattery; Mingyang Song; Shuji Ogino; Syed H. Zaidi; Michael Hoffmeister; Ulrike Peters
- Publisher
- Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 0016-5085)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)