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Derivatives of α-Tetronic Acid by A.G. Long; A.F. Turner is a Chemistry article available to read on EtoBox.

What is Derivatives of α-Tetronic Acid about?

ABRAHAM and NEWTON1 obtained the lactone (I) from cephalosporin C. We have studied simpler lactones of this type. We made our compounds from the Mannich bases derived from pyruvic acid, formaldehyde and certain secondary amines: 2 for instance, piperidine sulphate gave the a-tetronic acid derivative (III), from which the free base (IV) was obtained by treatment with barium hydroxide. We expected such Mannich bases to undergo substitution of the type advanced here to account for formation of the methylene derivative (V), CgHS06, a by-product\* (the "C15Hl,+010-Acid") in the preparation of the hydrochloride (II).

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Author
A.G. Long; A.F. Turner
Publisher
Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)
Published
1963
Language
EN
Field
Chemistry (Physical Sciences)

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