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The Acute Effect of Topical Beta‐adrenoreceptor Blocking Agents on Retinal and Optic Nerve Head Circulation by Oliver Arend; Alon Harris; Susanne Arend; Andreas Remky; B. J. Martin is a Medicine article available to read on EtoBox.

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## Purpose: Topical beta-blockers are the most common treatment for ocular hypertension in glaucoma, but their ocular hemodynamic effects are not well known. we investigated the acute effects of betaxolol (beta-1 selective antagonist), levobunolol (non-selective antagonist with active polar metabolite), and timolol (non-selective antagonist) on retinal and superficial optic nerve head circulation. ## Methods: Intraocular pressure (iop), heart rate, blood pressure, and retinal circulation were evaluated in 12 healthy subjects (6f/6m; mean age=24+/-2 years) before and two hours after instillation of each drug on separate occasions at least two weeks apart. macular capillary blood velocity (mcbv), epipapillary blood velocities (ebv), arteriovenous passage (avp) times, and arterial and venous diameters were measured by digital image analysis of scanning laser fluorescein angiograms. ## Results: All drugs significantly (p<0.05) reduced iop. there was no significant effect on blood pressure or calculated ocular perfusion pressure. only levobunolol significantly lowered heart rate (p<0.05). each drug produced a significant (p<0.01) decrease in avp time of approximately 25%. mcbv was signi

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Author

Oliver Arend; Alon Harris; Susanne Arend; Andreas Remky; B. J. Martin

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1395-3907)

Published

1998

Language

EN

Field

Medicine (Health Sciences)