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Case-control Single-marker and Haplotypic Association Analysis of Pedigree Data by Sharon R. Browning; J. David Briley; Linda P. Briley; Gyan Chandra; Jonathan H. Charnecki; Margaret G. Ehm; Kelley A. Johansson; Brendan J. Jones; Andrew J. Karter; David P. Yarnall; Michael J. Wagner is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Case-control Single-marker and Haplotypic Association Analysis of Pedigree Data about?
## Abstract Related individuals collected for use in linkage studies may be used in case‐control linkage disequilibrium analysis, provided one takes into account correlations between individuals due to identity‐by‐descent (IBD) sharing. We account for these correlations by calculating a weight for each individual. The weights are used in constructing a composite likelihood, which is maximized iteratively to form likelihood ratio tests for single‐marker and haplotypic associations. The method scales well with increasing pedigree size and complexity, and is applicable to both autosomal and X chromosomes. We apply the approach to an analysis of association between type 2 diabetes and single‐nucleotide polymorphism markers in the PPAR‐γ gene. Simulated data are used to check validity of the test and examine power. Analysis of related cases has better power than analysis of population‐based cases because of the increased frequencies of disease‐susceptibility alleles in pedigrees with multiple cases compared to the frequencies of these alleles in population‐based cases. Also, utilizing all cases in a pedigree rather than just one per pedigree improves power by increasing the effective sa
Who reads Case-control Single-marker and Haplotypic Association Analysis of Pedigree Data?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sharon R. Browning; J. David Briley; Linda P. Briley; Gyan Chandra; Jonathan H. Charnecki; Margaret G. Ehm; Kelley A. Johansson; Brendan J. Jones; Andrew J. Karter; David P. Yarnall; Michael J. Wagner
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0741-0395)
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)