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Enterovirus 71 isolated from China is serologically similar to the prototype E71 BrCr strain but differs in the 5′‐noncoding region by Dr. Zhi-Ming Zheng; Pei-Jun He; Diane Caueffield; Mark Neumann; Steven Specter; Carl C. Baker; Matthew J. Bankowski is a Medicine article available to read on EtoBox.

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## Abstract Enterovirus71 H (E71 H), an isolate from an adult patient with hand‐foot‐mouth disease (HFMD) in China, was serologically similar to the prototype strain E71 BrCr, which was isolated from a patient with aseptic meningitis. The study further analyzed the similarity of E71 H to E71 BrCr at the 5′‐noncoding region (NCR), a location in genomic RNA that recently was found to be related to neurovirulence in poliovirus and Venezuelan equine encephalitis virus. Using a reverse transcription‐polymerase chain reaction (RT‐PCR) technique and a unique primer pair I, a 397 bp product was detected from E7 I BrCr, Cox A9 (Griggs), Cox A16 (NIH), Cox B1 (HA antigen 201–4681, Cox 65 (wild type), and ECHO 11 (Gregory), but __not__ from E71 H, Cox A24 (Joseph), and ECHO 5 (Noyce). However, all of the viruses generated a 154 bp product using a universal enterovirus primer pair II. Further comparative analysis using primer‐directed sequencing of both the E71 H and E71 BrCr 154 bp products revealed that they differed by 12 bases. The variations between the two viruses were clustered in two loci, one in the region of nucleotides 43–61 with eight variations, and the other in the region of nucl

Who reads Enterovirus 71 isolated from China is serologically similar to the prototype E71 BrCr strain but differs in the 5′‐noncoding region?

Author

Dr. Zhi-Ming Zheng; Pei-Jun He; Diane Caueffield; Mark Neumann; Steven Specter; Carl C. Baker; Matthew J. Bankowski

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

1995

Language

EN

Field

Medicine (Health Sciences)