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High-Throughput Discovery of MHC Class I-And Ii - Restricted T Cell Epitopes Using Synthetic Cellular Circuits by thefolktalk is a document available to read on EtoBox.

What is High-Throughput Discovery of MHC Class I-And Ii - Restricted T Cell Epitopes Using Synthetic Cellular Circuits about?

The document outlines the development of TCR-MAP technology for mapping T cell receptor interactions with MHC class I and II, aimed at enhancing understanding of immune responses to cancer and infections. The methodology involves engineering Jurkat T cells, antigen presentation by APCs, and subsequent tagging and sorting of recognized peptides. Results indicate that TCR-MAP effectively identifies specific human TCR-pMHC interactions.

Author

thefolktalk

Language

EN