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Analysis of Buprenorphine by High-performance Liquid Chromatography by I.R. Tebbett is a Chemistry article available to read on EtoBox.

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Buprenorphine (temgesic) is a derivative of the opiate thebaine. It is a longacting analgesic with both narcotic agonist and antagonist actions'. Buprenorphine is often prescribed for the treatment of chronic post-operative pain and for terminal cancer patients2. It has also been used recently for the treatment of heroin addicts3. Buprenorphine is available as an injection for intramuscular or intravenous administration, and as sublingual tablets. The usual recommended doses are 200-600 pg by slow intravenous or intramuscular injection repeated every 6-8 h or 400 pg sublingually also every 6-8 h. However, there have been recent. reports of buprenorphine being abused by opiate addicts and doses of 3 mg per day sublingually or by injection have been commonly encountered4. This drug has a similar effect to morphine and pethidine but is more readily obtainable since it is not subject to the stringent restrictions associated with controlled drugs. The problem of buprenorphine abuse is apparently on the increasse and this situation has necessitated the search for a rapid method for the analysis of buprenorphine both in the form of pharmaceutical preparations and in blood samples of addic

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Author

I.R. Tebbett

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)

Published

1985

Language

EN

Field

Chemistry (Physical Sciences)