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The role of adenosine A1 receptors in the interaction between amygdala and entorhinal cortex of kindled rats by Mohammad Mohammad-Zadeh; Azam Amini; Javad Mirnajafi-Zadeh; Yaghoub Fathollahi is a Medicine article available to read on EtoBox.

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In this study the effect of adenosine A(1) receptors of the entorhinal cortex (EC) and amygdala on kindled seizures was investigated. Animals were kindled by daily electrical stimulation of amygdala (group 1) or EC (group 2). In the fully kindled animals, N(6)-cyclohexyladenosine (CHA), a selective A(1) receptor agonist, and 1,3-dimethyl-8-cyclopenthylxanthine (CPT), a selective A(1) receptor antagonist, were microinjected bilaterally into the EC (group 1) or amygdala (group 2). The seizure parameters were measured at 5, 15, 60 and 120 min post injection. Obtained data showed that in group 1, intra-EC microinjection of CHA at concentration of 10 microM reduced amygdala- and, EC-afterdischarge duration and stage 5 seizure duration at 5, 15, 60 and 120 min post drug injection. It also increased the latency to stage 4 seizure but no alteration was observed in seizure stage. At concentrations of 0.1 and 1 microM, CHA reduced only EC-afterdischarge duration at 5 and 15 min post drug infusion. Bilateral microinjection CPT at concentrations of 5 and 10 microM into the EC did not alter seizure parameters. Intra-EC microinjection of CPT (5 microM), 5 min before CHA (10 microM), blocked the

Who reads The role of adenosine A1 receptors in the interaction between amygdala and entorhinal cortex of kindled rats?

Author

Mohammad Mohammad-Zadeh; Azam Amini; Javad Mirnajafi-Zadeh; Yaghoub Fathollahi

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)

Published

2005

Language

EN

Field

Medicine (Health Sciences)