Opening book details…
Can I read PHF19 activates hedgehog signaling and promotes tumorigenesis in hepatocellular carcinoma on EtoBox?
PHF19 activates hedgehog signaling and promotes tumorigenesis in hepatocellular carcinoma by Shi Xiaoyun; Zi Yuyuan; Xing Jie; Nie Yingjie; Xie Qing; Deng Yuezhen; Xin Haiguang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is PHF19 activates hedgehog signaling and promotes tumorigenesis in hepatocellular carcinoma about?
Aberrant activation of Hedgehog-Gli1 signaling and accumulation of Gli1 in hepatocellular carcinoma (HCC) are frequently observed. However, the mechanisms leading to the overactivation of this signaling pathway are not fully understood. In this study, we show that the short isoform of PHD finger protein 19 (PHF19) interacts with β-TrCP, the E3 ligase of Gli1, and that knocking down PHF19 promotes the ubiquitination of Gli1. In a biological function study, PHF19 was found to promote the growth of HCC cells both in liquid culture and in soft agar. Moreover, knocking out PHF19 in a HCC mouse model (Myc) using the hydrodynamic method inhibited tumorigenesis and improved survival. Taken together, these results demonstrate that PHF19 promotes the growth of HCC cells by activating the Hedgehog signaling pathway.
Who reads PHF19 activates hedgehog signaling and promotes tumorigenesis in hepatocellular carcinoma?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Shi Xiaoyun; Zi Yuyuan; Xing Jie; Nie Yingjie; Xie Qing; Deng Yuezhen; Xin Haiguang
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)