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A miRNA expression signature that separates between normal and malignant prostate tissues by Jessica Carlsson; Sabina Davidsson; Gisela Helenius; Mats Karlsson; Zelmina Lubovac; Ove Andrén; Björn Olsson; Karin Klinga-Levan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is A miRNA expression signature that separates between normal and malignant prostate tissues about?

## Background MicroRNAs (miRNAs) constitute a class of small non-coding RNAs that post-transcriptionally regulate genes involved in several key biological processes and thus are involved in various diseases, including cancer. In this study we aimed to identify a miRNA expression signature that could be used to separate between normal and malignant prostate tissues. ## Results Nine miRNAs were found to be differentially expressed (__p__ <0.00001). With the exception of two samples, this expression signature could be used to separate between the normal and malignant tissues. A cross-validation procedure confirmed the generality of this expression signature. We also identified 16 miRNAs that possibly could be used as a complement to current methods for grading of prostate tumor tissues. ## Conclusions We found an expression signature based on nine differentially expressed miRNAs that with high accuracy (85%) could classify the normal and malignant prostate tissues in patients from the Swedish Watchful Waiting cohort. The results show that there are significant differences in miRNA expression between normal and malignant prostate tissue, indicating that these small RNA molecules might

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Author

Jessica Carlsson; Sabina Davidsson; Gisela Helenius; Mats Karlsson; Zelmina Lubovac; Ove Andrén; Björn Olsson; Karin Klinga-Levan

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1475-2867)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)