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Establishing a Reference System in Clinical Enzymology by Mauro Panteghini; Ferruccio Ceriotti; Gerhard Schumann; Lothar Siekmann is a Medicine article available to read on EtoBox.

What is Establishing a Reference System in Clinical Enzymology about?

The goal of standardization for measurements of catalytic concentrations of enzymes is to achieve comparable results in human samples, independent of the reagent kits, instruments and laboratory where the procedure is carried out. To pursue this objective, the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has launched a project to establish a reference system in clinical enzymology. This system is based on three hinges: a) extensively evaluated and carefully described reference procedures, b) certified reference materials and c) a network of reference laboratories operating in a highly controlled manner. The original IFCC-recommended procedures for alanine aminotransferase, aspartate aminotransferase, creatine kinase, gamma-glutamyltransferase, lactate dehydrogenase and alpha-amylase have been slightly modified to optimize them at 37 degrees C, with the definition of detailed operating procedures. A group of laboratories perform these procedures manually, with self-made reagents on carefully calibrated instruments. Partially purified and stabilized materials, prepared in the past by the Community Bureau of Reference, have been re-certified by these l

Who reads Establishing a Reference System in Clinical Enzymology?

Author

Mauro Panteghini; Ferruccio Ceriotti; Gerhard Schumann; Lothar Siekmann

Publisher

Walter de Gruyter GmbH

Published

2001

Language

EN

Field

Medicine (Health Sciences)