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What is Comparison of SpCas9 Variants for Genome Editing about?

This study evaluates the cleavage activity and specificity of 13 variants of Streptococcus pyogenes Cas9 (SpCas9) using high-throughput methods and deep learning models. The research identifies 156 out of 256 possible four-nucleotide PAM sequences that can be utilized by at least one SpCas9 variant, ranking their activities and specificities. The findings aim to assist in selecting the optimal Cas9 variant for specific genome editing applications.

Author

yongyao0919

Language

EN