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This study investigates the relationship between mechanical stretch and PI3K signaling in coordinating cell migration and proliferation during zebrafish pronephros morphogenesis. It demonstrates that fluid flow-induced collective epithelial migration leads to cell stretch, which signals for increased cell proliferation, particularly in the distal nephron. The findings suggest that kidney development is a recursive process where organ function influences cellular events, thereby shaping final organ morpholog

Author

DianaMateus

Language

EN