Can I read Vitamin D for infections on EtoBox?

Vitamin D for infections by Hannelie Korf; Brigitte Decallonne; Chantal Mathieu is a Medicine article available to read on EtoBox.

What is Vitamin D for infections about?

## Purpose of review Current data clearly support an interaction of vitamin D with cells of the immune system apart from its regulatory role in calcium homeostasis. The discovery that immune cells express the vitamin D receptor and are capable of metabolizing circulating 25-hydroxyvitamin D into its active form, 1,25-dihydroxyvitamin D, has revolutionized the field and suggested a regulatory role on both the innate and adaptive immune systems. ## Recent findings Of particular interest with respect to infectious diseases, 1,25-dihydroxyvitamin D has been shown to trigger the production of antimicrobial peptides with a direct pathogen-killing capacity. Interestingly, pathogen-derived components influence the key players in the vitamin D metabolizing pathway, further supporting such an interaction. ## Summary Here, we review the potential mechanisms of vitamin D in promoting the innate immune response against infectious agents and discuss the possible implications for such a response in the prevention of or the intervention in various infectious diseases.

Who reads Vitamin D for infections?

Author

Hannelie Korf; Brigitte Decallonne; Chantal Mathieu

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2014

Language

EN

Field

Medicine (Health Sciences)