Opening book details…
Can I read Autosomal-dominant locus for restless legs syndrome in French-Canadians on chromosome 16p12.1 on EtoBox?
Autosomal-dominant locus for restless legs syndrome in French-Canadians on chromosome 16p12.1 by Anastasia Levchenko; Jacques‐Yves Montplaisir; Géraldine Asselin; Sylvie Provost; Simon L. Girard; Lan Xiong; Emmanuelle Lemyre; Judith St‐Onge; Pascale Thibodeau; Alex Desautels; Gustavo Turecki; Claudia Gaspar; Marie‐Pierre Dubé; Guy A. Rouleau is a Medicine article available to read on EtoBox.
What is Autosomal-dominant locus for restless legs syndrome in French-Canadians on chromosome 16p12.1 about?
## Abstract We describe an autosomal‐dominant locus for Restless Legs Syndrome (RLS) in a French‐Canadian (FC) pedigree. Genome‐wide microsatellite scan and linkage analysis were used in this study. The locus maps to chromosome 16p12.1 and spans 1.18 Mega bases. The maximum multipoint LOD scores are of 3.5 over the total of 10 markers. Evidence for the same locus was also found in a smaller FC pedigree sime095. The analysis of the sequence of 8 annotated genes within the region did not reveal any pathogenic mutations. Copy number variation and karyotype analyses did not reveal any chromosomal abnormality in the region. Further analyses of the region are necessary to find the genetic cause of RLS in this family. © 2008 Movement Disorder Society
Who reads Autosomal-dominant locus for restless legs syndrome in French-Canadians on chromosome 16p12.1?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Anastasia Levchenko; Jacques‐Yves Montplaisir; Géraldine Asselin; Sylvie Provost; Simon L. Girard; Lan Xiong; Emmanuelle Lemyre; Judith St‐Onge; Pascale Thibodeau; Alex Desautels; Gustavo Turecki; Claudia Gaspar; Marie‐Pierre Dubé; Guy A. Rouleau
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)